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Master thesis in Biology



Master
thesis

«Early
changes in the brain after experimental subarachnoid hemorrhage in S1P
signaling mice»

Due to subarachnoid
hemorrhage (SAH), patients might develop an ischemic neurological damage with a
still unknown pathomechanism. Several studies suggest microvascular dysfunction
as one of the early pathological changes, which leads to BBB damage and tissue
hypoxia.

Since
sphingosine 1 phosphate is a lipid mediator, which is upon others involved in
regulating cell-cell adhesion, vascular development and vessel stability, the
aim of this study is to investigate the early outcome of SAH depending on the
stability of the vessels.



Your tasks:

Sectioning of
brain tissue, establishing and improving a proper IHC panel to visualize
microvascular damage followed by imaging and analysis of the occurring changes.




Starting
date:

Joining the
project is possible from today



Location:

Universitätsspital
Zürich



Questions
and applications:

johanna.schaffenrath@usz.ch

Publizierungsdatum: 17.07.2017 15:06:44
Name des Ansprechpartners: Johanna Schaffenrath
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